As the 2025 NFL season hits Week 6, several division races are starting to take shape — and BetMGM Sportsbook has released updated division odds and betting insights. From heavy favorites like the Bills and Buccaneers to competitive divisions such as the AFC North and NFC West, bettors are locking in their positions as the playoff picture begins to form.
Below is a breakdown of NFL division odds, public betting percentages, and biggest liabilities from BetMGM heading into Week 6.
AFC East Odds: Bills Heavy Favorites to Repeat
- Favorite: Buffalo Bills (-475)
- Highest Ticket %: Bills 36.5%
- Highest Handle %: Bills 86.3%
- Biggest Liability: Bills
The Buffalo Bills remain dominant favorites to win the AFC East, and the betting market reflects that confidence. With over 86% of the handle backing Buffalo, bettors are overwhelmingly siding with Josh Allen and company to capture another division crown. Miami and New York remain distant challengers, while the Patriots continue to rebuild.
AFC North Odds: Ravens Lead, but Steelers Steal the Action
- Favorite: Baltimore Ravens (+105)
- Highest Ticket %: Pittsburgh Steelers 42.3%
- Highest Handle %: Steelers 47.3%
- Biggest Liability: Cleveland Browns
The AFC North remains one of the NFL’s most unpredictable divisions. Despite the Ravens holding slight favorite status, Pittsburgh bettors are showing strong support, owning nearly half of all tickets and handle. The Cleveland Browns are BetMGM’s biggest liability in this division — a sign that sharp money could be backing them as a value play.
AFC South Odds: Colts Edge Jaguars in Tight Race
- Favorite: Indianapolis Colts (+100)
- Highest Ticket %: Jacksonville Jaguars 32.0%
- Highest Handle %: Houston Texans 48.0%
- Biggest Liability: Texans
The AFC South is wide open, with the Colts currently the betting favorite at even money. However, bettors are gravitating toward the Texans, who hold nearly half of the handle. Rookie quarterback play and offensive momentum could be fueling confidence in Houston to surprise the field down the stretch.
AFC West Odds: Chargers Favored, Broncos Draw Public Action
- Favorite: Los Angeles Chargers (+175)
- Highest Ticket %: Denver Broncos 45.7%
- Highest Handle %: Broncos 41.6%
- Biggest Liability: Broncos
The AFC West is not the powerhouse it once was, but Denver continues to draw heavy public interest. Despite the Chargers sitting as the current favorite, the Broncos lead both in ticket and handle percentage — making them BetMGM’s biggest liability in the division.
NFC East Odds: Eagles Still in Control
- Favorite: Philadelphia Eagles (-200)
- Highest Ticket %: New York Giants 27.1%
- Highest Handle %: Eagles 43.0%
- Biggest Liability: Giants
The Eagles maintain firm control of the NFC East with odds at -200, but Giants bettors are surprisingly active, representing over a quarter of all tickets. Philadelphia remains the most trusted team in terms of handle, while Dallas continues to lurk as a potential mid-season value play.
NFC North Odds: Lions Holding Steady
- Favorite: Detroit Lions (+100)
- Highest Ticket %: Lions 38.2%
- Highest Handle %: Lions 48.1%
- Biggest Liability: Lions
Detroit bettors are all-in on the Lions repeating as NFC North champions. Nearly half of all money wagered on the division has gone their way, making Detroit both the favorite and the sportsbook’s biggest liability. Minnesota and Green Bay have yet to inspire much market confidence as the Lions look to maintain control.
NFC South Odds: Buccaneers the Clear Front-Runner
- Favorite: Tampa Bay Buccaneers (-400)
- Highest Ticket %: Buccaneers 41.7%
- Highest Handle %: Buccaneers 55.1%
- Biggest Liability: Buccaneers
Tampa Bay stands as one of the biggest division favorites in the NFL heading into Week 6. With Baker Mayfield leading a balanced offense, bettors are firmly behind the Bucs, who dominate both ticket and handle percentages. The NFC South appears to be Tampa’s to lose.
NFC West Odds: 49ers Favored, but Seahawks Draw Interest
- Favorite: San Francisco 49ers (-125)
- Highest Ticket %: Seattle Seahawks 28.4%
- Highest Handle %: 49ers 28.5%
- Biggest Liability: Seahawks
The NFC West remains a two-team race between San Francisco and Seattle. While the 49ers are the betting favorite, Seahawks bettors are keeping things interesting, representing the highest ticket percentage and BetMGM’s biggest liability in the division. Expect this race to tighten as the season progresses.
NFL Division Betting Outlook Heading Into Week 6
With several divisions already showing heavy favorites and others still wide open, Week 6 provides key opportunities for futures bettors to find value. Teams like the Texans, Steelers, and Seahawks present intriguing underdog options, while Buffalo, Tampa Bay, and Philadelphia continue to command dominant betting support.
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